No association between mutations in the human androgen receptor GGN repeat and inter-sex conditions
نویسندگان
چکیده
منابع مشابه
No association between mutations in the human androgen receptor GGN repeat and inter-sex conditions.
The functional role of the GGN repeat in the human androgen receptor gene is unknown, although mutations in this region have been found in patients with inter-sex conditions. We have investigated the prevalence of GGN mutations in the androgen receptor in the Swedish population and their relation to male reproductive function. A physical examination and semen analysis was carried out in 223 men...
متن کاملassociation of androgen receptor ggn repeat length polymorphism and male infertility in khuzestan, iran
background: androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. the human androgen receptor (ar) encoding gene contains two regions with three nucleotide polymorphic repeats (cag and ggn) in the first exon. unlike the cag repeats, the ggn has been less studied because of technical difficulties, so the functional role ...
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BACKGROUND Androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. The human androgen receptor (AR) encoding gene contains two regions with three nucleotide polymorphic repeats (CAG and GGN) in the first exon. Unlike the CAG repeats, the GGN has been less studied because of technical difficulties, so the functional role o...
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Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, an...
متن کاملAssociations between androgen receptor CAG & GGN repeat polymorphism & recurrent spontaneous abortions in Chinese women
BACKGROUND & OBJECTIVES Recurrent spontaneous abortion (RSA) is a reproductive problem that occurs in women in reproductive age with a frequency of 1-3 per cent. Previous studies have reported high levels of serum androgens to be associated with RSAs. At the molecular level, the effect of androgens is mediated through the activation of the androgen receptor (AR). The CAG and GGN repeat polymorp...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2003
ISSN: 1460-2407
DOI: 10.1093/molehr/gag048